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Vented Individual Patient (VIP) Hoods for the Control of Infectious Airborne Diseases in Healthcare Facilities Review

J. Patel, F. McGain, T. Bhatelia, S. Wang, B. Sun, J. Monty, V. Pareek

Engineering 2022, Volume 15, Issue 8,   Pages 126-132 doi: 10.1016/j.eng.2020.12.024

Abstract: of separating the airborne emissions of patients from the air breathed by healthcare workers (HCWs), ventedindividual patient (VIP) hoods, a form of local exhaust ventilation (LEV), offer a new approach to reduceResults from recent studies have demonstrated that, for typical patient-emitted aerosols, VIP hoods provideUnlike a mask, hood performance can be easily monitored and HCWs can be alerted to failure by alarms.The broader concept of individual patient hoods has the potential to be expanded beyond ventilation to

Keywords： COVID-19     Vented individual patient hood     Airborne transmission     Healthcare worker     Infectious disease    

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Exhaust hood for steam turbines-single-flow arrangement

Michal HOZNEDL , Ladislav TAJC , Jaroslav KREJCIK , Lukas BEDNAR , Kamil SEDLAK , Jiri LINHART ,

Frontiers in Energy 2009, Volume 3, Issue 3,   Pages 321-329 doi: 10.1007/s11708-009-0039-4

Abstract: In the past, increased attention was given to the development of an optimal shape for the inlet part of LP turbine casings in SKODA POWER. A double-flow design is typically used for high power output turbines. An optimized shape for the internal diffuser has been found, which transforms the kinetic energy of steam into increased pressure, thus effectively increasing the thermodynamic efficiency of the stage. Some conclusions have been drawn from laboratory experiments, others derived directly from on-site measurements at power plants. The conclusions from the development of double-flow turbines form the basis for the design of the single-flow turbine arrangement. Single-flow design is typically used for lower output turbines. There are still some limitations in applying this arrangement. The designer needs to resolve the bearing position and how to ensure access to them. Reinforcing the ribs and supports are used, therefore, to ensure the rigidity of the entire casing. The optimization of the single-flow diffuser shape is therefore the subject of the study presented below.

Keywords： exhaust hood     steam turbines     single-flow arrangement    

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Development trend of urban design in “digital age”: Pan-dimensionality and individual-ubiquity

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 3,   Pages 569-575 doi: 10.1007/s11709-021-0735-7

Abstract: ., the urban development is moving toward “pan-dimensionality” and “individual ubiquity”.

Keywords： digital age     urban design     multiple objectives     human-computer interaction     pan-dimensionality     individual-ubiquity    

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Leveraging individual-level data to advance air pollution health risk management

Jianxun YANG, Wenjing WU, Miaomiao LIU, Jun BI

Frontiers of Engineering Management 2022, Volume 9, Issue 2,   Pages 337-342 doi: 10.1007/s42524-022-0189-1

Abstract: Individual cofactors such as risk perceptions of air pollutants, baseline health conditions, and socioThus, individual-level exposure and health assessment are critical in advancing the engineering management

To perform air pollution health risk assessment and management at the individual level, firstThese monitors can illustrate individual time–activity patterns and assess personal-specific pollution

In this comment, we summarize different types of individual-level data and outline pathways

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Erratum to: On the potential of iPhone significant location data to characterize individual mobility

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 9, doi: 10.1007/s11783-022-1556-1

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On the potential of iPhone significant location data to characterize individual mobility for air pollution

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 5, doi: 10.1007/s11783-022-1542-7

Abstract:

● We evaluated the accuracy of iPhone data in capturing time-activity patterns.

Keywords： Air pollution exposure     Human mobility     iPhone     Significant Location     Smartphone data    

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Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report

Haiyan He, Ran An, Jian Hou, Weijun Fu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 284-286 doi: 10.1007/s11684-017-0514-y

Abstract: In this report, we present a rare side effect, rhabdomyolysis, in a 68-year-old female APL patient who

Keywords： arsenic trioxide     APL     rhabdomyolysis    

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Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research

Shuyang Sun,Zhiyuan Zhang

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 104-110 doi: 10.1007/s11684-016-0432-4

Abstract: Patient-derived xenograft (PDX) models generated from human tumor samples that can retain the histologicalthe translational value of this well-annotated PDX panel in the development of co-clinical trials for patient

Keywords： patient-derived xenograft models     personalized medicine     co-clinical trial     patient stratification     oral    

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An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

Xiang Du

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 506-509 doi: 10.1007/s11684-013-0294-y

Abstract:

This study aimed to investigate patient dose in diagnostic screen-film radiographic examinations in

Keywords： radiation dosage     radiology     radiation protection     radiography/statistics & numerical data    

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Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: To identify the potential pathogenic mutations in a Chinese patient with CF, we conducted Sanger sequencingon the genomic DNA of the patient and his parents and detected all 27 coding exons of CFTR andThe patient is a compound heterozygote of c.2909G>A, p.Gly970Asp in exon 18 and c.1210-3C>G in cisOverall, c.1210-3C>G, the newly identified pathogenic mutation in our patient, in combination with T5Moreover, this patient carries a p.Gly970Asp mutation, thus confirming the high-frequency of this mutation

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibits the activation of immune cells through the interaction with its ligand CD24 on tumor cells. Here, by analyzing public databases containing 64 517 patients of 33 cancer types, we found that the expression of Siglec10 was altered in 18 types of cancers and was associated with the clinical outcomes of 11 cancer types. In particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRC) and was inversely associated with the prognosis of the patients. In 131 KIRC patients of our settings, Siglec10 was elevated in the tumor tissues of 83 (63.4%) patients compared with that in their counterpart normal kidney tissues. Moreover, higher level of Siglec10 was associated with advanced disease (stages III and IV) and worse prognosis. Silencing of CD24 in KIRC cells significantly increased the number of Siglec10-expressing macrophages phagocytosing KIRC cells. In addition, luciferase activity assays suggested that Siglec10 was a potential target of the transcription factors c-FOS and GATA1, which were identified by data mining. These results demonstrate that Siglec10 may have important oncogenic functions in KIRC, and represents a novel target for the development of immunotherapies.

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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Xingnao Kaiqiao acupuncture combined with Angong Niuhuang Wan for a patient under persistent vegetative

Hujie Song, Xiao Chen, Yalan Yu, Ling Zhang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 334-339 doi: 10.1007/s11684-017-0539-2

Abstract: Our patient is a male and 5 years and 3 months of age.

Keywords： PVS     stubborn disease     Xingnao Kaiqiao     Angong Niuhuang Wan     TCM     acupuncture    

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Ventricular tachycardia in a disseminated MDR-TB patient: a case report and brief review of literature

Hui Li,Ran Li,Jiuxin Qu,Xiaomin Yu,Zhixin Cao,Yingmei Liu,Bin Cao

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 259-263 doi: 10.1007/s11684-014-0321-7

Abstract:

Although significant breakthroughs have been achieved in tuberculosis management, we still encounter numerous difficulties in diagnosis and treatment of the disease. Additionally, a new challenge, multidrug-resistant tuberculosis (MDR-TB) with unspecific clinical presentation, often results in delayed diagnosis. In this paper, we reported a case of disseminated tuberculosis with rare presentation of ventricular fibrillation, which proved resistant to both isoniazid and rifampicin. A review of literature showed that ventricular fibrillation or tachycardia in tuberculosis patients with pericarditis or myocarditis has been sporadically reported in the past, but none has been conducted involving patients with MDR-TB infections.

Keywords： tuberculosis     MDR-TB     ventricular tachycardia    

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Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis B: a case report

Lei Li,Yimei Liu,Tiancheng Luo,Jian Zhou,Yingyong Hou,Xizhong Shen,Jiyao Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 250-253 doi: 10.1007/s11684-014-0333-3

Abstract:

The clinical data of a patient with acute-on-chronic liver failure were analyzed retrospectively.The patient has suffered from hepatitis B for 30 years.The patient also presented hepatocellular carcinoma.The patient recovered uneventfully and was discharged after surgery.

Keywords： acute-on-chronic liver failure     submassive necrosis     viral hepatitis B     esophageal variceal bleeding     liver transplantation    

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Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device Article

Lyle Hood,Rudy T. Andriani,Tobias E. Ecker,John L. Robertson,Christopher G. Rylander

Engineering 2015, Volume 1, Issue 3,   Pages 344-350 doi: 10.15302/J-ENG-2015077

Abstract:

Convection-enhanced delivery (CED) is a promising technique leveraging pressure-driven flow to increase penetration of infused drugs into interstitial spaces. We have developed a fiberoptic microneedle device for inducing local sub-lethal hyperthermia to further improve CED drug distribution volumes, and this study seeks to quantitatively characterize this approach in agarose tissue phantoms. Infusions of dye were conducted in 0.6% (w/w) agarose tissue phantoms with isothermal conditions at 15 °C, 20 °C, 25 °C, and 30 °C. Infusion metrics were quantified using a custom shadowgraphy setup and image-processing algorithm. These data were used to build an empirical predictive temporal model of distribution volume as a function of phantom temperature. A second set of proof-of-concept experiments was conducted to evaluate a novel fiberoptic device capable of generating local photothermal heating during fluid infusion. The isothermal infusions showed a positive correlation between temperature and distribution volume, with the volume at 30 °C showing a 7-fold increase at 100 min over the 15 °C isothermal case. Infusions during photothermal heating (1064 nm at 500 mW) showed a similar effect with a 3.5-fold increase at 4 h over the control (0 mW). These results and analyses serve to provide insight into and characterization of heat-mediated enhancement of volumetric dispersal.

Keywords： near-infrared laser     thermochemotherapy     agarose     photothermal heating     micro-catheter     malignant glioma    

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Title Author Date Type Operation

Vented Individual Patient (VIP) Hoods for the Control of Infectious Airborne Diseases in Healthcare Facilities

J. Patel, F. McGain, T. Bhatelia, S. Wang, B. Sun, J. Monty, V. Pareek

Journal Article

Exhaust hood for steam turbines-single-flow arrangement

Michal HOZNEDL , Ladislav TAJC , Jaroslav KREJCIK , Lukas BEDNAR , Kamil SEDLAK , Jiri LINHART ,

Journal Article

Development trend of urban design in “digital age”: Pan-dimensionality and individual-ubiquity

Journal Article

Leveraging individual-level data to advance air pollution health risk management

Jianxun YANG, Wenjing WU, Miaomiao LIU, Jun BI

Journal Article

Erratum to: On the potential of iPhone significant location data to characterize individual mobility

Journal Article

On the potential of iPhone significant location data to characterize individual mobility for air pollution

Journal Article

Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report

Haiyan He, Ran An, Jian Hou, Weijun Fu

Journal Article

Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research

Shuyang Sun,Zhiyuan Zhang

Journal Article

An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

Xiang Du

Journal Article

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

Xingnao Kaiqiao acupuncture combined with Angong Niuhuang Wan for a patient under persistent vegetative

Hujie Song, Xiao Chen, Yalan Yu, Ling Zhang

Journal Article

Ventricular tachycardia in a disseminated MDR-TB patient: a case report and brief review of literature

Hui Li,Ran Li,Jiuxin Qu,Xiaomin Yu,Zhixin Cao,Yingmei Liu,Bin Cao

Journal Article

Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis B: a case report

Lei Li,Yimei Liu,Tiancheng Luo,Jian Zhou,Yingyong Hou,Xizhong Shen,Jiyao Wang

Journal Article

Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device

Lyle Hood,Rudy T. Andriani,Tobias E. Ecker,John L. Robertson,Christopher G. Rylander

Journal Article